Increases cortisol levels and provides non-glandular ingredients important for adrenal health, energy, wakefulness, and stress management*
Key ingredients
Glycyrrhizic acid (from Licorice root extract): Glycyrrhetinic acid (metabolite of glycyrrhizic acid) binds 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) to inhibit the breakdown of cortisol (1, 2).*
L-histidine: Precursor to histamine. In the central nervous system, histamine plays an important role in the release of pituitary hormones and wakefulness (3).
L-methionine: Precursor to S-adenosylmethionine (SAMe) (4). SAMe is directly involved in methylation processes including catecholamine synthesis (5).
L-tyrosine: Precursor to catecholamines including dopamine, norepinephrine, and epinephrine.
Rhodiola Rosea root extract (5% rosavins): Adaptogen that has been shown to reduce stress-induced effects (6, 7).* In a randomized, double-blind, placebo-controlled study, Rhodiola Rosea was shown to significantly improve mental fatigue and general well-being under stress (7).*
Green tea leaf extract (Camellia sinensis) (65% EGCG): Epigallocatechin gallate (EGCG) is a polyphenol in green tea that provides antioxidant protection by its ability to scavenge free radicals and metal ions (8).* EGCG has been shown to increase resistance to fatigue in animal models (9).*
Vitamins B and C: Active forms of pantothenic acid, niacin, B6, folate, B12, and C are important for the synthesis of adrenal hormones and neurotransmitters (10-14).*
References
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- Mischoulon D and Fava M. Am J Clin Nutr. 2002;76(5):1158S-61S.
- Chiang H, et al. J Food Drug Anal. 2015;23(3):359-69.
- Spasov A, et al. Phytomedicine. 2000;7(2):85-9.
- Legeay S, et al. Nutrients. 2015;7(7):5443-68.
- Teng Y and Wu D. Pharmacogn Mag. 2017;13(50):326-31.
- Ragaller V, et al. J Anim Physiol Anim Nutr (Berl). 2011;95(1):6-16.
- Vrecko K, et al. Biochim Biophys Acta. 1997;1361(1):59-65.
- May J, et al. Brain Res Bull. 2013;90:35-42.
- Antoniades C, et al. Circulation. 2006;114(11):1193-201.
- Mattson M and Shea T. Trends Neurosci. 2003;26(3):137-46.
