Decreases cortisol levels and provides ingredients important for calm, sleep, and management of blood sugar*
Lagerstroemia speciosa (Banaba) leaf extract (2% corosolic acid): Corosolic acid selectively inhibits 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), an enzyme that catalyzes the conversion of cortisone into cortisol (1, 2).* In a randomized study, corosolic acid was shown to significantly lower blood glucose levels by 20-30% after two weeks (3).*
Phosphatidylserine: Component of cell membranes important for receptor-mediated interactions (4).* Phosphatidylserine is thought to interact with cell membranes in order to dampen hypothalamic signaling and regulate the stress response (5).*
Glycine: Major inhibitory neurotransmitter that crosses the blood-brain barrier (6).* Binds receptors that regulate temperature during sleep (7).*
Taurine: Neuroprotective amino acid that provides antioxidant protection and demonstrates GABA-A agonist activity (8-10).* GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep (11-13).
References
- Rollinger J, et al. Bioorg Med Chem. 2010;18(4):1507-15.
- Patel H, et al. Arabian Journal of Chemistry. 2015.
- Judy W, et al. J Ethnopharmacol. 2003;87(1):115-7.
- Monteleone P, et al. Eur J Clin Pharmacol. 1992;41:385-8.
- Glade M and Smith K. Nutrition. 2015;31(6):781-6.
- Kawai N, et al. Amino Acids. 2012;42(6):2129-37.
- Kawai N, et al. Neuropsychopharmacology. 2015;40(6):1405-16.
- Kumari N, et al. Adv Exp Med Biol. 2013;775:19-27.
- Shimada K, et al. Adv Exp Med Biol. 2015;803:581-96.
- Kletke O, et al. PLoS One. 2013;8(4):e61733.
- Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
- Mohler H. Neuropharmacology. 2012;62(1):42-53.
- Saper C, et al. Nature. 2005;437(7063):1257-63.
