Contains ingredients important for regulating the stress response, reducing anxiousness, and sleep*
Key ingredients
Rhodiola Rosea root extract (15% rosavins): Adaptogen shown to reduce anxiousness and stress-related effects (1, 2).*
Phosphatidylserine: Component of cell membranes important for receptor-mediated interactions (3).* Phosphatidylserine is thought to interact with cell membranes in order to dampen hypothalamic signaling and regulate the stress response (4).*
Glycine: Major inhibitory neurotransmitter that crosses the blood-brain barrier (5).* Binds receptors that regulate temperature during sleep (6).*
Taurine: Neuroprotective amino acid that provides antioxidant protection and demonstrates GABA-A agonist activity (7-9).* GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep (10-12).
References
- Bystritsky A, et al. J Altern Complement Med. 2008;14(2):175-80.
- Olsson E, et al. Planta Med. 2009;75(2):105-12.
- Monteleone P, et al. Eur J Clin Pharmacol. 1992;41:385-8.
- Glade M and Smith K. Nutrition. 2015;31(6):781-6.
- Kawai N, et al. Amino Acids. 2012;42(6):2129-37.
- Kawai N, et al. Neuropsychopharmacology. 2015;40(6):1405-16.
- Kumari N, et al. Adv Exp Med Biol. 2013;775:19-27.
- Shimada K, et al. Adv Exp Med Biol. 2015;803:581-96.
- Kletke O, et al. PLoS One. 2013;8(4):e61733.
- Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
- Mohler H. Neuropharmacology. 2012;62(1):42-53.
- Saper C, et al. Nature. 2005;437(7063):1257-63.
