Digest-ProGD is a broad spectrum proprietary enzyme blend, providing unique support for the digestion of gluten and dairy proteins, as well as lactose, other carbohydrates, proteins and fats. It contains Dipeptidyl peptidase IV (DPP-IV), a multifunctional serine protease that targets proline containing peptides, such as those found in gliadin and casein, which are both proteolytically resistant proteins.1, 2, 3 DPP-IV is thought to be one of the rate limiting enzymes responsible for the digestion of these proteins. It is known to be found in lower amounts in the intestinal mucosa of individuals with celiac disease and to have an inverse correlation with the level of mucosal damage among those with and without celiac disease.4, 5 The antigenic and immunomodulatory proline-rich proteins found in gluten are thought to trigger an inflammatory response in patients with either celiac disease or gluten sensitivity, often due to inadvertent gluten exposure, even for those on a gluten free diet.6 Digest-ProGD provides comprehensive digestive support, containing multiple proteases as well as enzymes necessary for lipid and carbohydrate metabolism.
Benefits
- Contains essential proteases I, II, III, IV and IV, stable throughout the pH range of the digestive tract
- Each capsule delivers a standardized level of DPP-IV activity and is shown to survive the harsh environment of the stomach
- Hydrolyzes difficult-to-digest proline-containing peptides such as gluten and casein
- Contains amylase and glucoamylase that assist in the hydrolysis of carbohydrates as well as the enzyme lactase
- Provides alpha-galactosidase for the digestion of oligosaccharides found in beans, other legumes and cruciferous vegetables
- Suitable for vegetarians/vegans, and gluten and casein free diets
References
1. Mulvihill EE, Drucker DJ. Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors. Endocr Rev. 2014 Dec;35(6):992-1019. doi:10.1210/er.2014-1035.
2. Nongonierma AB, FitzGerald RJ. Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chem. 2014 Feb 15;145:845-52. doi:10.1016/j. foodchem.2013.08.097.
3. Lambeir AM, Durinx C, Scharpé S, De Meester I. Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci. 2003 Jun;40(3):209-94.
4. Hausch F, Shan L, Santiago NA, et al. Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol. 2002 Oct;283(4):G996-G1003.
5. Detel D, Persic M, Varljen J. Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac disease. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):65-70.
6. Cerf-Bensussan N, Matysiak-Budnik T, Cellier C, Heyman M. Oral proteases: a new approach to managing coeliac disease. Gut. 2007 Feb;56(2):157-60. Epub 2006 Sep 1.
