Contains ingredients shown to improve sleep and reduce vasomotor symptoms*
GABA is the primary inhibitory neurotransmitter in the brain, which means it plays a central role in balancing the excitability of neurons (1). Because of this reason, GABA is important for promoting sleep, calm, and managing stress (2-4). Stress is thought to alter GABA synthesis and activity by affecting the expression of GABA-synthesizing enzymes and receptors (5).
Serotonin is important for modifying the thermoregulatory set point (6). This means supporting serotonin may help to ameliorate hot flashes (7). Kavinace Flash-Ease contains 5-HTP (precursor to serotonin) and two botanicals with serotonergic activity (ashwagandha and black cohosh) (8, 9).* Ashwagandha supports a healthy stress response, while black cohosh exhibits GABAergic and potentially selective estrogenic activity (8, 10, 11).* In a randomized, double-blind, placebo-controlled study, black cohosh significantly reduced vasomotor symptoms, improved sleep quality, and reduced wakefulness after falling asleep (12).*
References
- Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
- Mohler H. Neuropharmacology. 2012;62(1):42-53.
- Saper C, et al. Nature. 2005;437(7063):1257-63.
- Mody I and Maguire J. Front Cell Neurosci. 2012;6:4.
- Maguire J. Front Cell Neurosci. 2014;8:157.
- Bruck K and Zeisberger E. Pharmacol Ther. 1987;35(1-2):163-215.
- Freedman R. et al. Menopause. 2011;18(8):893-6.
- Wuttke W, et al. J Steroid Biochem Mol Biol. 2014;139:302-10.
- Kaurav B, et al. Asian Pac J Trop Med. 2012;5(5):380-4.
- Auddy B, et al. J Am Neutraceut Assoc. 2008;11:50-56.
- Jarry H, et al. Maturitas. 2003;44 Suppl 1:S31-8.
- Jiang K, et al. Climacteric. 2015;18(4):559-67.
