L-Glutamine with Theracurmin

• Provides 5 g L-glutamine and 30 mg Theracurmin per serving
• Targets multiple pathways of inflammation and protein synthesis to improve muscle repair and recovery following exercise
• Provides immune and digestive system support
• Theracurmin has higher bioavailability compared to standard curcumin in humans9
• Powder formulation allows for flexible and convenient dosing
• Suitable for vegetarians/vegans

L-glutamine is the most plentiful amino acid in the body, a Krebs cycle intermediary of particular importance to intestinal and immune cells, and one known to be depleted following strenuous physical activity.1 L-glutamine supplementation has been shown to prevent an exercise-induced increase in intestinal permeability, by promoting tight junction stability, upregulating anti-inflammatory cytokine production, and suppressing inflammation, notably NF-κB activation.2 L-glutamine also stimulates protein synthesis pathways, while inhibiting protein degradation.3

Curcumin has well-established anti-inflammatory effects with multiple molecular targets, including NF-κB, as well as cyclooxygenases and lipoxygenases.4,5 Curcumin supplementation has been shown to mitigate damage to muscles following exercise, reduce pain due to delayed onset muscle soreness, and enhance the recovery of muscle performance.6 Theracurmin specifically has been shown to prevent both an increase in creatine kinase and muscle degradation following eccentric exercise.7 Theracurmin has been proven effective for symptom relief and a reduced need for rescue medication among participants with knee osteoarthritis in a prospective clinical trial.8 L-glutamine and Theracurmin combined target multiple mechanisms associated with muscle repair and function.

References

1. Agostini F, Biolo G. Effect of physical activity on glutamine metabolism. Curr Opin Clin Nutr Metab Care. 2010 Jan;13(1):58-64.
2. Zuhl M, Dokladny K, Mermier C, et al. The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells. Cell Stress Chaperones. 2015 Jan;20(1):85-93.
3. Lambertucci AC, Lambertucci RH, Hirabara SM, et al. Glutamine supplementation stimulates protein-synthetic and inhibits protein-degradative signaling pathways in skeletal muscle of diabetic rats. PLoS One. 2012;7(12):e50390.
4. Shakibaei M, John T, Schulze-Tanzil G, et al. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol. 2007 May 1;73(9):1434-45.
5. Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr. 2010 Aug 21;30:173-99.
6. Nicol LM, Rowlands DS, Fazakerly R, et al. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol. 2015 Aug;115(8):1769-77.
7. Tanabe Y, Maeda S, Akazawa N, et al. Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin. Eur J Appl Physiol. 2015 Sep;115(9):1949-57.
8. Nakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014 Nov;19(6):933-9. doi: 10.1007/s00776-014-0633-0.
9. Sasaki H, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011;34(5):660-5.
10. Samocha-Bonet D, Chisholm DJ, et al. Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study. PLoS One. 2014 Nov 20;9(11):e113366.