Vitamin D and vitamin K have diverse and complementary physiological functions, close associations with age-related and chronic diseases, and a strong body of clinical evidence documenting widespread insufficiency and therapeutic potential.1, 2 Vitamin D has both hormonal and non-hormonal functions, with vitamin D receptors translating into a myriad of physiological actions, ranging from bone metabolism to modulation of immune activity.
Vitamin D regulates the expression of hundreds of genes, influences cellular proliferation and signaling, insulin production and sensitivity, and is a critical inhibitor of several inflammatory pathways.5, 6
Vitamin K-dependent (VKD) proteins also have a nearly ubiquitous presence and regulate diverse functions including cellular growth, arterial calcification and bone metabolism.12 Vitamins K and D have complementary physiological functions, and clinical trials have shown synergistic benefit for both osteoporosis and cardiovascular disease when used together.
•Provides clinically effective doses of vitamins D and K per softgel
•Vitamin D3 has the highest potency for increasing serum and storage levels of vitamin D
•Uses the optimal form of vitamin K, vitamin K2 Menaquinone-7 (MK-7)
•MK-7 has the longest half-life and best extra-hepatic distribution of all forms
•A D3 and MK-7 combination has a synergistic benefit compared to single nutrient therapy